A tophus can occur when you have gout and uric acid builds up around your joints. Larger tophi need to be removed so they don’t cause long-term damage.

Chronic gout, sometimes called gouty arthritis, can lead to a number of complications if left untreated. These include joint damage and joint deformity, tophi, loss of mobility, loss of bone ...

Tophi feel like hard bumps under the skin and are usually not painful, except during gout attacks when they become inflamed and swollen. As tophi continue to grow, they can erode the surrounding ...

This study demonstrates that gout patients from the US and three EU countries suffer from significantly decreased HRQOL, with the average patient suffering decreased mental as well as physical ...

Pegloticase quickly resolved tophi among patients with gout who responded to the treatment, according to data published in Arthritis Research & Therapy.“Pegloticase is a recombinant mammalian ...

A negative correlation was seen for joint effusions (OR 0.316, 95% CI 0.231-0.432, P<0.001). Further analysis determined that increased numbers of tophi exacerbated risks of erosions.

Background Although typically a late feature of gout, tophi may present early in the course of disease. The aim of this study was to identify factors associated with the presence of early ...

Both excessive and long-term alcohol consumption, as well as any spirit consumption, predict the development of ultrasound-detected tophi and sub-tophi in patients with gout, according to data ...

Although arthroscopic removal is the usual treatment for intra-articular tophi, surgery is not always an option. This Case Study demonstrates that continuous urate-lowering therapy is a suitable ...

Tophi can develop anywhere in our bodies but is most commonly found in people's toes, heels, knees, fingers, ears, forearms of even in the elbow. Article continues below.

In a phase 2 global trial, 42 patients with gout and subcutaneous tophi were randomly assigned to receive once-daily AR882 (75mg), AR882 (50mg) plus allopurinol, or allopurinol alone (titrated up ...