Activation-induced cytidine deaminase (AID) plays a crucial role in the immune system by facilitating somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. These processes ...

Antibody drugs have reshaped how we treat diseases. By harnessing the immune system to destroy tumours or temper excessive inflammation in autoimmune disorders, these therapeutics have become ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

“Dr. Dennis Burton's group and others have shown that you require a substantial amount of somatic hypermutation over the context of many exposures to evolve these bNAbs. Work from Dr. Michel ...

Results: BCR-seq of both twins revealed convergent antibody characteristics including V-gene use, CDRH3 lengths and somatic hypermutation (SHM). Further, antibody clonotypes with genetic features ...

The current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or develop organized lymphoid structures, ...

The drug candidate acts by targeting PD-1 immune checkpoint. It is developed based on the somatic hypermutation (SHM) platform. It was under development of alopecia areata, graft versus host disease, ...

Therefore, all sequence alignments are based on differences in amino acid sequences without considering factors such as somatic hypermutation, and thus may not accurately reflect the actual nucleic ...

The enormously complex, multifactorial and highly regulated cellular processes that generate receptor variation in somatic cells arose through the integration of molecular systems that are not ...

which could somewhat explain the sudden interest in somatic exercises. Said to be a bit like yoga, a bit like meditation and yet their own thing entirely, somatic exercises are trending on social ...

Articles were selected for inclusion if they reported on patients with metastatic prostate cancer who received a germline or somatic genomic test and/or made comparisons between those tests, reported ...