As per the National Health Service (NHS) recommends that men and women between 19 to 64 years should take a daily dose of 300 mg and 270 mg of magnesium, respectively.

TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...

A U of A researcher recently created a new class of drugs that targets and kills cancer cells with less damage to healthy ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...

1Department of Molecular and Systems Biology, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire.

Although the exact mechanism of cisplatin toxicity is still unclear, oxidative stress, inflammation, mitochondrial damage, endoplasmic reticulum stress (ER stress), apoptosis, and DNA damage are ...

2013). The Role of Phosphorylation on Tau Cytotoxicity and Aggregation Mitochondrial dysfunction and oxidative stress are both intimately associated with cell death in neurodegeneration. Mitochondrial ...

In addition, iron-mediated oxidative stress not only triggers neuronal damage, but also exacerbates neuronal dysfunction by altering the phosphorylation of N-methyl-D-aspartate receptors and ...

Defects in the oxidative phosphorylation (OXPHOS) system — the final biochemical pathway in the production of ATP — result in devastating, mainly multisystem diseases. The OXPHOS system is ...

Surprisingly, P-TEFb exhibits Ser5 phosphorylation activity in vitro. The mechanism garnering Ser2 specificity to P-TEFb remains elusive and hinders understanding of the transition from transcription ...

Despite an increase in glycolysis, however, here we show that non-transformed mouse fibroblasts also increase oxidative phosphorylation (OXPHOS) by nearly two-fold and mitochondrial coupling ...