A tophus can occur when you have gout and uric acid builds up around your joints. Larger tophi need to be removed so they don’t cause long-term damage.

Tophi are firm, painless yellow lesions that form in and around the joints in people with advanced gout. They have a uric acid (monosodium urate) core, and the skin that covers them can become ...

Despite outdated misconceptions, gout is still very much a current health concern that affects millions of Americans. ... Tophi can deform joints and cause lasting damage to bones and tissues.

The Food and Drug Administration (FDA) has granted Fast Track designation to AR882 for the treatment of clinically visible tophi in patients with gout. AR882 is an investigational selective uric ...

Background Although typically a late feature of gout, tophi may present early in the course of disease. The aim of this study was to identify factors associated with the presence of early ...

Both excessive and long-term alcohol consumption, as well as any spirit consumption, predict the development of ultrasound-detected tophi and sub-tophi in patients with gout, according to data ...

This study demonstrates that gout patients from the US and three EU countries suffer from significantly decreased HRQOL, with the average patient suffering decreased mental as well as physical ...

KUALA LUMPUR: Patients suffering from gout are advised not to remove the uric acid fluid from tophi, or lumps that form under the skin, themselves, as this can lead to the risk of a life ...

I suffer from Gout and a day has not gone past since my 26th birthday that I have not had it in a joint somewhere. I have tried Puricos & Allomaron with no success. I have now developed Tophi on my ...

Apart from that, your joint may feel swollen, red, and warm. Gout flares usually occur in one joint and can be triggered by certain foods, alcohol, certain medications, physical trauma, or certain ...

Arthrosi to present positive phase 2 data for its novel selective URAT1 inhibitor AR882 in patients with tophaceous gout at ACR convergence 2023. News release. Arthrosi Therapeutics.