This important study shows, for the first time, the structure and snapshots of the dynamics of the full-length soluble Angiotensin-I converting enzyme dimer. The combination of structural and ...

Enzymes, the core catalysts in life, drive critical biological processes ranging from metabolic regulation to energy ...

You may have heard of the fantastic-sounding "dark side of the genome." This poorly studied fraction of DNA, known as ...

New research offers unprecedented insight into how an enigmatic enzyme, known as CDK7, drives the cell cycle and cell proliferation.

The lock and key model explains how enzymes work: The enzyme is like a "lock". The substrate (the molecule it reacts with) is like a "key" that fits into the lock. Each enzyme is specific and acts ...

Determining enzyme mechanisms includes determining their kinetic and thermodynamic properties. This study proposes an unreported molecular mechanism of substrate inhibition in enzymes. It shows ...

HDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its ...

So if a human finds, for instance, a better but more complex way to make a knife, they can pass along the new instructions. One of those learners might stumble upon their own improvement and pass ...

While these improvements enhance the study, the study is incomplete due to the lack of enzyme-substrate complex structures and reliance on modeling which still limit mechanistic insight. Nonetheless, ...