Activity and Dosage of Alteplase Dilution For Clearing Occlusions of Venous-Access Devices Stephanie N. Davis, Lee Vermeulen, Jane Banton, Bradford S. Schwartz, and Eliot C. Williams Disclosures ...

Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular reocclusion may occur after intravenous thrombolysis and may be preventable wi ...

For the matter of expanded indications of FDA-approved therapies, the authors presented alteplase (Activase, Genentech) and tenecteplase (TNKase, Genentech) as contrasting, viable answers to ...

Alteplase is also sold by Boehringer in the UK under the Actilyse brand. According to NICE, Metalyse costs less than alteplase, so could save the NHS millions of pounds when used as a stroke ...

Fibrin-specific plasminogen activator TNKase (tenecteplase) is the first stroke medicine approved by the FDA in nearly 30 years, joining Roche/Genentech's Activase (alteplase), which is the only ...

How long can certain drugs be left unrefrigerated before they are unusable? A useful list provides information on 89 commonly used medications.

Background Despite high recanalization rates with endovascular thrombectomy (EVT) for large vessel occlusions, functional outcomes remain suboptimal. This study investigates whether adjunctive ...

Many observational studies in patients with stroke (including both ischemic and ICH) have found that use of prehospital notification to the destination ED is associated with faster time to ...

Purpose— Much has transpired since the last scientific statement on pediatric stroke was published 10 years ago. Although stroke has long been recognized as an adult health problem causing substantial ...

Background and Purpose Healthcare systems in the United States are increasingly transitioning from alteplase (TPA) to tenecteplase (TNK) as primary thrombolytic in acute ischemic stroke care. We ...