That the talks are even happening represents a historic moment, given the decades of enmity between the two countries since the 1979 Islamic Revolution and the U.S. Embassy hostage crisis.

Iran and the United States will hold talks Saturday in Rome, their second round of negotiations over Tehran’s rapidly advancing nuclear program. The talks follow a first round held in Muscat, Oman, where the two sides spoke face to face.

A second round of nuclear talks between the United States and Iran is underway, as what both sides are looking for in a deal begins to take shape. Delegations from both countries met in Oman last weekend for talks mediated by the Gulf Arab nation.