Tophi are a symptom of gout. They are large, hardened masses of uric acid crystals within and around the joints. These masses can cause pain, joint deformity, and limited range of motion.

Her general practitioner diagnosed gouty arthritis because of a high serum uric-acid level (600 µmol/l; normal range 270–380 µmol/l) coexistent with tophi in her hands, and initiated ...

The previous paragraphs described certain gout scenarios where a faster crystal ... leads to the disappearance of acute attacks and tophi – which may be considered as the cure of the disease ...

Other symptoms can include: Decreased range of motion Redness Swelling in finger joints Warm or hot skin around the affected ...

dose-ranging clinical study in refractory gout patients with or without tophi, to evaluate the efficacy and safety of a 10, 30, or 60 mg tablet dose of SAP-001. The study enrolled 87 patients from ...

and dissolve tophi in gout and tophaceous gout patients, today announced the completion of enrollment for its pivotal global Phase 3 REDUCE 2 trial. Arthrosi Logo (PRNewsfoto/Arthrosi Therapeutics ...

Recurring gout is often due to the deposition of urate crystals in bumps or nodules called tophi which generally are not painful but during flares of gout can become extremely painful. Those with ...

Arthrosi Therapeutics doses first patient in replicate pivotal phase 3 REDUCE 1 trial of lead compound AR882: San Diego Wednesday, March 19, 2025, 11:00 Hrs [IST] Arthrosi Therape ...

and dissolve tophi in gout and tophaceous gout patients, today announced that it has dosed the first patient in REDUCE 1, the Company's second pivotal Phase 3 clinical trial evaluating AR882.