Antibody drugs have reshaped how we treat diseases. By harnessing the immune system to destroy tumours or temper excessive inflammation in autoimmune disorders, these therapeutics have become ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the induction of high-affinity antibodies derived from GCs and produced by ...

“Dr. Dennis Burton's group and others have shown that you require a substantial amount of somatic hypermutation over the context of many exposures to evolve these bNAbs. Work from Dr. Michel ...

The current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or develop organized lymphoid structures, ...

As you can imagine, this type of somatic mimicry can create confusion in regard to what to do: Some people will rush to the emergency room, while others may experience even greater anxiety as they ...

The enormously complex, multifactorial and highly regulated cellular processes that generate receptor variation in somatic cells arose through the integration of molecular systems that are not ...

Here, we provide an overview of the potential for chromosomal copy number changes, somatic nuclear and mitochondrial DNA mutations, single nucleotide polymorphisms, and T and B cell receptor sequences ...

This study provides useful insights into the ways in which germinal center B cell metabolism, particularly lipid metabolism, affects cellular responses. The authors use sophisticated mouse models to ...

Venoms are complex mixtures of toxic compounds delivered by bite or sting. In humans, the consequences of envenomation range from self-limiting to lethal. Critical host defence against envenomation ...

A study in the journal Pharmaceuticals has uncovered how specific genetic mutations in α2δ-1 and α2δ-3 proteins linked to autism spectrum disorders (ASD) alter neuronal functionality. These ...