Analyzing Saturday’s San Diego Padres at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

Get Chicago vs San Diego baseball betting preview, spread and over/under insights for their matchup on April 5.

The San Diego Padres took their unblemished record on the road for the first time in 2025. Unfortunately for the team and ...

The Chicago Cubs will face off against the San Diego Padres in their 2025 home opener at Wrigley Field Friday.

Hey, 161-1 is still on the table. On a festive Friday afternoon at Wrigley Field, the Padres’ club-record season-opening ...

Two clubs on winning streaks — the San Diego Padres (seven straight) and the Chicago Cubs (three in a row) — play on Friday ...

San Diego qualified for the NCAA Tournament this season in its ... Christian and Alexis then welcome on Chicago Fire ...

For the second straight year, Shota Imanaga got the ball for the home opener at Wrigley Field. And the sequel was even better ...

Runners left in scoring position_San Diego 3 (Cronenworth 2, Gurriel); Chicago 5 (Crow-Armstrong 2, Swanson, Hoerner 2). RISP_San Diego 0 for 4; Chicago 1 for 5. Runners moved up_Sheets.

Photos from the Chicago Cubs’ home opener against the San Diego Padres on April 4, 2025.

San Diego Padres' pitcher Nick Pivetta impressed fans with his debut against the Braves. As the Padres prepare to face the Cubs at Wrigley Field on Ap ...

The Padres’ 7-0 record is the best of any team that the Cubs have hosted in a home opener. They have welcomed eight other ...