By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory ...

Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if they’ll ...

Researchers discovered how to flip the structure of complex drug compounds using a simple reagent, offering a game-changing ...

The SAIR database is designed to help scientists train AI models to better predict protein-ligand binding affinities for drug discovery.

Molecular structure of tuberculosis efflux pump reveals how bacteria resist key antibiotic by Jeff Hansen, University of Alabama at Birmingham edited by Sadie Harley, reviewed by Robert Egan ...

The structure showed 12 transmembrane helices in two pseudo-symmetric bundles and two periplasmic subdomains. Experiments showed that the coiled-coil domain, whose predicted model extends from one of ...

A newly identified centromeric structure, the CENP-A–H4 octasome, may reveal how chromosomes segregate properly during cell division, report researchers from Japan. Using cryo-electron ...

Researchers made small tweaks to the molecular structure of LSD to see if it could be turned into an effective brain-healing treatment.

Astronomers using ALMA have discovered a new type of long, narrow “slim filaments” in the Milky Way’s central molecular zone, revealing surprising details about shock-induced material circulation near ...

A new study led by researchers at the Earth-Life Science Institute (ELSI) at Institute of Science Tokyo has uncovered a surprising role for calcium in shaping life's earliest molecular structures.

Neo-1 is the first model to unify de novo molecular generation and atomic-level structure prediction in a single model, by generating latent representations of whole molecules instead of ...

Structure’s lead amylin-based molecule, ACCG-2671, is a DACRA that is being evaluated for use either alone or in combination with GLP-1R agonists to treat obesity and associated diseases. ACCG-2671 is ...