Intravenous thrombolysis with alteplase is the only approved treatment for acute ischemic stroke, but its efficacy and safety when administered more than 3 hours after the onset of symptoms have no ...

Of 256 patients enrolled, 118 were randomly assigned to receive heparin plus alteplase and 138 to receive heparin plus placebo. The incidence of the primary end point was significantly higher in ...

When administered within 4 to 5 hours of stroke onset, the thrombolytic drug alteplase significantly increased the likelihood of a positive outcome, researchers reported in The Lancet.Although ...

Activity and Dosage of Alteplase Dilution For Clearing Occlusions of Venous-Access Devices Stephanie N. Davis, Lee Vermeulen, Jane Banton, Bradford S. Schwartz, and Eliot C. Williams Disclosures ...

Alteplase was prepared (1) at a concentration of 1 mg/ mL and stored as a 1-mL portion in a polypropylene tube at -20°C for six months or (2) as a 2-mL portion in glass borosilicate vials at -70 ...

Patients with minor nondisabling acute ischemic stroke who were treated with alteplase vs. aspirin did not experience an increased likelihood of favorable functional outcome after 90 days ...

Boehringer Ingelheim (BI) is celebrating after an independent evaluation in the UK has reconfirmed that the benefits of its clot-busting drug alteplase outweigh the risks for acute ischaemic stroke.

Intracranial hemorrhage during hospitalization after alteplase administration: 9.9% with NOACs vs 7.4% with no anticoagulants (OR 1.37, 95% CI 0.62-3.03) ...

HealthDay News — For patients with ischemic stroke, tenecteplase seems to be a reasonable alternative to alteplase in terms of effectiveness and safety outcomes, according to a study published ...

The stroke drug alteplase is safe and effective between three and 4.5 hours post-stroke, as well as within the conventional three-hour treatment window. This is the conclusion of authors of an ...

HealthDay News — Reteplase is noninferior to alteplase for patients with ischemic stroke within 4.5 hours after symptom onset, according to a study published online June 14 in the New England ...

For the new study, researchers compared nearly 9,500 patients who received tenectplase for stroke to more than 70,000 who got alteplase between July 2020 and June 2022.