Invasive cardiopulmonary exercise testing is required to diagnose exercise-induced pulmonary arterial hypertension (PAH), exercise-induced heart failure with preserved ejection fraction (HFpEF), and ...

Background and Purpose:Natriuretic peptides have led the way as a diagnostic and prognostic tool for the diagnosis and management of heart failure (HF). More recent evidence suggests that natriuretic ...

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a multifunctional ...

Aim: The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical ...

Background—The noninvasive assessment of altered myocardium in patients with genetic mutations that are associated with hypertrophic cardiomyopathy (HCM) remains challenging. In this pilot study, we ...

Data on the predictive value of coronary computed tomography angiography–derived fractional flow reserve (CT‐FFR) for long‐term outcomes are limited.

The epicardial adipose tissue (EAT) of metabolic syndrome (MetS) is abnormally accumulated with dysfunctional secretion of adipokines, closely relating to cardiac dysfunction. The current study was ...

Ischemic stroke in younger adults is far less common than that among older adults, yet the underlying pathogeneses and risk factors are more diverse. Approximately 10% to 15% of all strokes occur in ...

Cardiovascular disease (CVD) remains a major health burden despite significant therapeutic advances accomplished over the last decades. It is widely and increasingly recognized that systemic ...

The Editors of Circulation: Cardiovascular Quality and Outcomes are pleased to announce a new Patient or Caregiver Viewpoint section in the Journal. Viewpoints will be authored by patients or their ...

Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. Many proximal signals and signal transduction pathways activated during ...

Background—MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular ...