Open in Viewer Figure 1. Invasive cardiopulmonary exercise test results. A, Analysis of the case vignette patient’s key functional performance measures demonstrates that the maximum respiratory ...

A number of biomarkers associated with HF are well recognized, and measuring their concentrations in circulation can be a convenient and noninvasive approach to provide important information about ...

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a multifunctional ...

Aim: The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical ...

Background—The noninvasive assessment of altered myocardium in patients with genetic mutations that are associated with hypertrophic cardiomyopathy (HCM) remains challenging. In this pilot study, we ...

Coronary computed tomography angiography (CCTA) has long been considered a gatekeeper for invasive coronary angiography because of its high sensitivity and negative predictive value. However, there ...

Epicardial adipose tissue (EAT) is mostly located in atrioventricular and interventricular sulcus, which can extend to the apex of the heart. The weight of EAT is only 0.02% of total fat and has no ...

Ischemic stroke in younger adults is far less common than that among older adults, yet the underlying pathogeneses and risk factors are more diverse. Approximately 10% to 15% of all strokes occur in ...

Cardiovascular disease (CVD) remains a major health burden despite significant therapeutic advances accomplished over the last decades. It is widely and increasingly recognized that systemic ...

In keeping with the scope of the Journal, we hope that many Viewpoints will contain insights from the patient’s perspective along with suggestions on how to improve clinical care and healthcare ...

Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. Many proximal signals and signal transduction pathways activated during ...

Background—MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular ...