Theranos founder and former chief executive Elizabeth Holmes has lost an appeal against her conviction for defrauding investors in her blood-testing company. Holmes was sentenced to more than 11 years in prison.

Elizabeth Holmes lost her bid to overturn her conviction, leaving the founder of the defunct blood-testing technology startup Theranos with few remaining legal options.Holmes is currently serving an 11-year sentence at an all-female federal prison camp in Bryan,

The three-judge panel in San Francisco also upheld the fraud conviction of Holmes’ former business partner and lover Ramesh “Sunny” Balwani — as well as a lower’s court order for the two to pay $452 million in restitution.