Somatic hypermutation of immunoglobulin genes occurs at both C·G pairs and A·T pairs. Mutations at C·G pairs are created by activation-induced deaminase (AID)-catalysed deamination of C ...

Somatic hypermutation, gene conversion and class-switch recombination are genetic rearrangements that generate the molecular diversity of immunoglobulin genes underlying the human immune system. In ...

Although the somatic hypermutation process, which typically results in point mutations, and SHA indels have been shown to be linked, 5, 6, 7 it is unclear as to whether the location of SHA indels ...

Enhancers serve to restrict potentially dangerous hypermutation to antibody genes Date: April 1, 2014 Source: PLOS Summary: How B lymphocytes are able to direct mutations to their antibody genes ...

Only clonotypes that contained immunoglobulin G1 (IgG1)-expressing B lymphocytes somatic hypermutation ... "Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants".

Study: An ancestral vaccine induces anti-Omicron antibodies by hypermutation.Image Credit: Lightspring / Shutterstock *Important notice: bioRxiv publishes preliminary scientific reports that are ...

Background: Temozolomide, a commonly used alkylating agent to treat gliomas, can induce somatic hypermutation. The prevalence and clinical implications of this phenomenon are not well characterized.