Somatic hypermutation of immunoglobulin genes occurs at both C·G pairs and A·T pairs. Mutations at C·G pairs are created by activation-induced deaminase (AID)-catalysed deamination of C ...

Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes, to generate high-affinity B-cell antigen receptors. But, as discussed in this Review, how SHM is ...

Somatic hypermutation, gene conversion and class-switch recombination are genetic rearrangements that generate the molecular diversity of immunoglobulin genes underlying the human immune system. In ...

GCB lymphomas express hundreds of genes that define germinal-center B cells. 16,37,41 The malignant clone continues to undergo somatic hypermutation, 42 and the cells have often switched IgH ...

Enhancers serve to restrict potentially dangerous hypermutation to antibody genes Date: April 1, 2014 Source: PLOS Summary: How B lymphocytes are able to direct mutations to their antibody genes ...

Antibody somatic hypermutation (SHM) is a pivotal step in antibody diversification. During SHM, the antibody genes undergo various mutational events, such as point mutations, deletions, and ...

Risk for disease progression among patients with chronic lymphocytic leukemia (CLL) over time differed between those with mutated or unmutated disease, showing that gene somatic hypermutation plays a ...

Using the same strain of yeast that ferments wine and makes dough rise, a team led by University of California, Irvine and Harvard Medical School researchers has developed an in vitro technology ...

Only clonotypes that contained immunoglobulin G1 (IgG1)-expressing B lymphocytes somatic hypermutation ... "Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants".

Marilia Cascalho was educated in medicine (M.D., University of Lisbon) and in genetics, molecular biology and immunology (Ph.D. UCSF). She completed a post-doctoral fellowship at the Hagedorn Research ...