In light sheet–based fluorescence microscopy (LSFM), optical sectioning in the excitation process minimizes fluorophore bleaching and phototoxic effects. Because biological specimens survive ...

Light-sheet fluorescence microscopy is a state-of-the art imaging technique for live-cell imaging. Unlike traditional imaging techniques such as laser scanning and spinning disk confocal ...

Light sheet microscopy with curved light sheets enables tiling-free imaging of an entire intact cleared mouse brain with lateral and axial spatial resolutions of 1.0 μm and 2.5 μm, respectively ...

The first light-sheet microscope was created in 1903 by Siedentopf & Zsigmondy. 2 Their goal to analyze sub-resolution gold particles earned them the first-ever Nobel prize awarded for a ...

Light-sheet microscopy is one of the most powerful method for imaging the development and function of whole living organisms. However, achieving high-resolution images with these microscopes ...

JENA, Germany & SEATTLE, May 06, 2025--ZEISS and Alpenglow Biosciences today announced a new partnership to jointly develop an inverted light-sheet microscope and bioinformatics pipeline tailored ...

1. Development of a two-photon excitation light-sheet microscope which achieves low phototoxicity, an extended field of view, and high resolution for the observation of the growth of living ...

Open-top light-sheet microscopy is used to rapidly acquire 3D images of fluorescently labeled tissues that have been treated in a way that makes them transparent or translucent.

Volumetric imaging of the 3D orientation of cellular structures with a polarized fluorescence light-sheet microscope. Proceedings of the National Academy of Sciences , 2025; 122 (8) DOI: 10.1073 ...

At the annual meeting of the American Society for Cell Biology (ASCB) in Philadelphia, PA, USA, from December 6 to 10, 2014, Leica Microsystems offers visitors a preview of its latest development: a ...

New Inverted Light-Sheet Microscopy Platform for Research and Clinical Applications Provided by Business Wire May 6, 2025, 2:05:00 PM.