Microvillus inclusion disease: From organoids to new treatments
These cells had been pretty screwed up before ... for the development of therapeutic approaches in microvillus inclusion ...
Sickle cell disease is a genetic disorder that causes lifelong suffering – here’s what you need to know
Accumulation of clots causes some of the most severe symptoms of sickle cell disease, including strokes, kidney failure, ...
eLife1d
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...
Health Affairs8d
Filling The Gaps: The Urgent Need For Sickle Cell Disease Data
Our fundamental challenge is not simply to create the data. Rather, it is to collect and analyze it systematically. Doing so ...