Frosolone is a comune in the Province of Isernia in the Italian region Molise, located about 20 kilometres west of Campobasso and about …Frosolone is a comune in the Province of Isernia in the Italian region Molise, located about 20 kilometres west of Campobasso and about 20 kilometres east of Isernia. It is one of I Borghi più belli d'Italia. Frosolone is known historically for the production of blades, including knives and scissors, and is home to a museum dedicated to the craft.